Поздняя нейротоксичность противоопухолевого лечения у детей: часть 1 (С.А. Кулева, М.Б. Белогурова, Б.А. Колыгин)

S.A. Kulyova, M.B. Belogurova, B.A. Kolygin

Аннотация


Комплексный подход играет важную роль при лечении злокачественных опухолей у детей. Тем не менее, эта терапия может привести к различным отдаленным последствиям, включая нейротоксичность. Клиническая практика нередко демонстрирует возникновение периферических и центральных нейропатий. Их патофизиология не совсем понятна. Недавние исследования показали, что нейропатии обладают гетерогенностью, особенно в анатомической локализации, а также в клинической, электрофизиологической и нейровизуализационной симптоматике. В статье представлен обзор исследований по поздней нейротоксичности, возникающей после химиотерапии, хирургического и лучевого лечения.
Ключевые слова: дети, злокачественная опухоль, поздние осложнения лечения, нейротоксичность.

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Литература


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