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BASIC IMMUNOLOGY. Textbook for foreign medical students (Основы иммунологии). 2-е издание

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Описание

Авторы: Lyudmila V. Gankovskaya, Leila S. Namazova-Baranova, Marina A. Stenina, Vyacheslav V. Grechenko,Marina V. Horeva, Oksana A. Svitich, Galina A. Ignatieva, Evgenia V. Sokolova, Tatyana V. Gromova,Almira D. Donetskova, Aleksandr L. Kovalchuk

Reviewers:Yudina S.M., doctor of medical sciences, professor, Head of the Department of Clinical Immunologyand Allergology, Kursk State Medical UniversitySergeev O.V., doctor of biological sciences, professor, Department of Microbiology, Virology andImmunology, Faculty of Medicine and Prevention, Sechenov First Moscow State Medical University(Sechenov University), Ministry of Health of the Russian Federation

Год издания: 2021

Количество страниц: 108

ISBN:978-5-6045954-4-2

Издательство: ПедиатрЪ

This manual is a presentation of the basics of General Immunology: the structure of the immune system
and the common rules of its functioning. Up-to-date characteristics of the main mechanisms of innate and
adaptive immunity are also discussed. Separate chapters are devoted to the characterization of immune cells,
differentiation of T- and B-lymphocytes, cytokines and antibodies. The structure and functions of the human
major histocompatibility complex and features of the development of immune reactions are described in greater
detail.
In addition, this manual contains a list of questions for self-control testing and has plenty of illustrations
to facilitate focused learning. This structure of the manual will help students to highlight important aspects of
Immunology as a discipline and to gain fundamental knowledge in all studied processes, as well as to achieve
better understanding, help organize, bring focus and structure into the study.
Manual is intended for students of Medical Universities studying «Immunology» as a discipline in the
English language, under specialty code 05.31.01 «General Medicine».
The publication is a translation from Russian of an updated version of the first chapter of the textbook
«Basic Immunology for Dentists» published by Paediatrician Publishers in 2019. The book you are holding is
the second edition.

Содержание

Introduction

Immune system, structural and functional features. The concept of innate and adaptive immunity

Structural and functional organization of the immune system
The central organs of the immune system
Peripheral organs and tissues of the immune system

Structures recognized by the immune system
Antigens and haptens
Definition of antigen, the main properties of antigens
Types of antigens
Structures recognized by the innate immune system

Innate immunity
Recognition of «foreign» by the innate immune system. Innate immune receptors
Cells of the innate immune system
  Innate cells of the myeloid lineage
  Lymphoid cells with innate immunity functions
Humoral factors of the innate immune system

Major histocompatibility complex
MHC structure and functions
Discovery
Genetic map of the human major histocompatibility complex
Features of the major histocompatibility complex
MHC class I molecules
MHC class II molecules
Endogenous antigen processing pathway
Exogenous antigen-processing pathway
HLA disease association

Cytokines
Classification of cytokines
Characteristics of cytokine-producing cells. Concept of Th1, Th2 and Th17 subpopulations
Characteristics of some cytokines
Cytokine receptors
Cytokines and inflammation. Local and systemic effects of cytokines

Adaptive immunity
T-lymphocytes. The main markers and receptors. Features of antigen recognition.
The main subpopulations, the functions of lymphocytes
  Main characteristics of T-lymphocytes
  The structure of the T-cell receptor
  T-lymphocyte development
B-lymphocytes. The main markers and receptors. Specifics of antigen recognition. The main subpopulations and functions
  Main characteristics of B-lymphocytes
  Subpopulations of B-lymphocytes
  BCR structure
  B-lymphocyte markers
  Antigen-independent differentiation of B-lymphocytes
Antibodies.
  General characteristics and structure of the antibody molecule
  Mechanisms of antigen-antibody interactions
  Properties and effector functions of immunoglobulins
  Characteristics of the main classes of immunoglobulins

Immune response
Phases of the immune response
Types of immune response and factors determining the development of an immune response
Cell-mediated-cytotoxicity
Stages of cytotoxic immune response
Humoral immune response
Mucosal immunity

Bibliography
Main literature
Additional literature