BASIC IMMUNOLOGY. Textbook for foreign medical students (Основы иммунологии)
Описание
Авторы: Lyudmila V. Gankovskaya, Leila S. Namazova-Baranova, Marina A. Stenina, Vyacheslav V. Grechenko,Marina V. Horeva, Oksana A. Svitich, Galina A. Ignatieva, Evgenia V. Sokolova, Tatyana V. Gromova,Almira D. Donetskova, Aleksandr L. Kovalchuk
Reviewers:Yudina S.M., doctor of medical sciences, professor, Head of the Department of Clinical Immunologyand Allergology, Kursk State Medical UniversitySergeev O.V., doctor of biological sciences, professor, Department of Microbiology, Virology andImmunology, Faculty of Medicine and Prevention, Sechenov First Moscow State Medical University(Sechenov University), Ministry of Health of the Russian Federation
Год издания: 2019
Количество страниц: 108
ISBN: 978-5-6042577-0-8
Издательство: ПедиатрЪ
This manual is a presentation of the basics of General Immunology: the structure of the immune systemand the common rules of its functioning. Up-to-date characteristics of the main mechanisms of innate andadaptive immunity are also discussed. Separate chapters are devoted to the characterization of immune cells,differentiation of T- and B-lymphocytes, cytokines and antibodies. The structure and functions of the humanmajor histocompatibility complex and features of the development of immune reactions are described in greaterdetail.In addition, this manual contains a list of questions for self-control testing and has plenty of illustrationsto facilitate focused learning. This structure of the manual will help students to highlight important aspects ofImmunology as a discipline and to gain fundamental knowledge in all studied processes, as well as to achievebetter understanding, help organize, bring focus and structure into the study.Manual is intended for students of Medical Universities studying «Immunology» as a discipline in theEnglish language, under specialty code 05.31.01 «General Medicine».The publication is a translation from the Russian of the updated version of the first chapter of the textbook«Basic Immunology for dentists» published by Paediatrician Publishers in 2019.
содержание
Introduction
Immune system, structural and functional features. Th e concept of innateand adaptive immunity
Structural and functional organization of the immune system
Th e central organs of the immune system
Peripheral organs and tissues of the immune system
Structures recognized by the immune system
Antigens and haptens
Defi nition of antigen, the main properties of antigens
Types of antigens
Structures recognized by the innate immune system
Innate immunity
Recognition of «foreign» by the innate immune system. Innate immune receptors
Cells of the innate immune system
Innate cells of the myeloid lineage
Lymphoid cells with innate immunity functions
Humoral factors of the innate immune system
Major histocompatibility complex
MHC structure and functions
Discovery
Genetic map of the human major histocompatibility complex
Features of the major histocompatibility complex
MHC class I molecules
MHC class II molecules
Endogenous antigen processing pathway
Exogenous antigen-processing pathway
HLA disease association
Cytokines
Classifi cation of cytokines
Characteristics of cytokine-producing cells. Concept of Th 1, Th 2and Th 17 subpopulations
Characteristics of some cytokines
Cytokine receptors
Cytokines and infl ammation. Local and systemic eff ects of cytokines
Adaptive immunity
T-lymphocytes. Th e main markers and receptors. Features of antigen recognition.Th e main subpopulations, the functions of lymphocytes
Main characteristics of T-lymphocytes
Th e structure of the T-cell receptor
T-lymphocyte development
B-lymphocytes. Th e main markers and receptors. Specifi cs of antigenrecognition. Th e main subpopulations and functions
Main characteristics of B-lymphocytes
Subpopulations of B-lymphocytes
BCR structure
B-lymphocyte markers
Antigen-independent diff erentiation of B-lymphocytes
Antibodies.
General characteristics and structure of the antibody molecule
Mechanisms of antigen-antibody interactions
Properties and eff ector functions of immunoglobulins
Characteristics of the main classes of immunoglobulins
Immune response
Phases of the immune response
Types of immune response and factors determining the developmentof an immune response
Cell-mediated-cytotoxicity
Stages of cytotoxic immune response
Humoral immune response
Mucosal immunity
Bibliography
Main literature
Additional literature