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BASIC IMMUNOLOGY. Textbook for foreign medical students (Основы иммунологии)

250 500


Авторы: Lyudmila V. Gankovskaya, Leila S. Namazova-Baranova, Marina A. Stenina, Vyacheslav V. Grechenko,Marina V. Horeva, Oksana A. Svitich, Galina A. Ignatieva, Evgenia V. Sokolova, Tatyana V. Gromova,Almira D. Donetskova, Aleksandr L. Kovalchuk

Reviewers:Yudina S.M., doctor of medical sciences, professor, Head of the Department of Clinical Immunologyand Allergology, Kursk State Medical UniversitySergeev O.V., doctor of biological sciences, professor, Department of Microbiology, Virology andImmunology, Faculty of Medicine and Prevention, Sechenov First Moscow State Medical University(Sechenov University), Ministry of Health of the Russian Federation

Год издания: 2019

Количество страниц: 108

ISBN: 978-5-6042577-0-8

Издательство: ПедиатрЪ

This manual is a presentation of the basics of General Immunology: the structure of the immune systemand the common rules of its functioning. Up-to-date characteristics of the main mechanisms of innate andadaptive immunity are also discussed. Separate chapters are devoted to the characterization of immune cells,differentiation of T- and B-lymphocytes, cytokines and antibodies. The structure and functions of the humanmajor histocompatibility complex and features of the development of immune reactions are described in greaterdetail.In addition, this manual contains a list of questions for self-control testing and has plenty of illustrationsto facilitate focused learning. This structure of the manual will help students to highlight important aspects ofImmunology as a discipline and to gain fundamental knowledge in all studied processes, as well as to achievebetter understanding, help organize, bring focus and structure into the study.Manual is intended for students of Medical Universities studying «Immunology» as a discipline in theEnglish language, under specialty code 05.31.01 «General Medicine».The publication is a translation from the Russian of the updated version of the first chapter of the textbook«Basic Immunology for dentists» published by Paediatrician Publishers in 2019.



Immune system, structural and functional features. Th e concept of innateand adaptive immunity

Structural and functional organization of the immune system

Th e central organs of the immune system

Peripheral organs and tissues of the immune system

Structures recognized by the immune system

Antigens and haptens

Defi nition of antigen, the main properties of antigens

Types of antigens

Structures recognized by the innate immune system

Innate immunity

Recognition of «foreign» by the innate immune system. Innate immune receptors

Cells of the innate immune system

Innate cells of the myeloid lineage

Lymphoid cells with innate immunity functions

Humoral factors of the innate immune system

Major histocompatibility complex

MHC structure and functions


Genetic map of the human major histocompatibility complex

Features of the major histocompatibility complex

MHC class I molecules

MHC class II molecules

Endogenous antigen processing pathway

Exogenous antigen-processing pathway

HLA disease association


Classifi cation of cytokines

Characteristics of cytokine-producing cells. Concept of Th 1, Th 2and Th 17 subpopulations

Characteristics of some cytokines

Cytokine receptors

Cytokines and infl ammation. Local and systemic eff ects of cytokines

Adaptive immunity

T-lymphocytes. Th e main markers and receptors. Features of antigen recognition.Th e main subpopulations, the functions of lymphocytes

Main characteristics of T-lymphocytes

Th e structure of the T-cell receptor

T-lymphocyte development

B-lymphocytes. Th e main markers and receptors. Specifi cs of antigenrecognition. Th e main subpopulations and functions

Main characteristics of B-lymphocytes

Subpopulations of B-lymphocytes

BCR structure

B-lymphocyte markers

Antigen-independent diff erentiation of B-lymphocytes


General characteristics and structure of the antibody molecule

Mechanisms of antigen-antibody interactions

Properties and eff ector functions of immunoglobulins

Characteristics of the main classes of immunoglobulins

Immune response

Phases of the immune response

Types of immune response and factors determining the developmentof an immune response


Stages of cytotoxic immune response

Humoral immune response

Mucosal immunity


Main literature

Additional literature

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